Warped by Speed - Contaminant DNA enters cells, replicates after mass production failed to filter

Almost a year ago, when contaminant plasmid DNA was first detected in Pfizer’s COVID shots, America’s Frontline Doctors warned in an Issue Brief that the plasmid DNA could potentially enter the cells of the person injected and cause a wide variety of unknowns. Regulatory agencies across the world denied that this was possible — now, however, their denials have been proven false.

Warped by Speed

Plasmids, DNA molecules usually found in bacteria, that carry genes but float independently of chromosomal DNA and can replicate on their own, were never supposed to be in the COVID shots in the first place. 

The reason plasmids were found in COVID jabs, by multiple researchers working independently, is that when the shots were produced on mass scale (as things were necessarily done differently in order to speed up the process), filtration ended up being sub-par and not all the contaminants were removed.

COVID spike protein mRNA was produced (by both Moderna and Pfizer) by taking bacteria and using it to grow DNA, which was encoded for the spike protein and then used to make a synthetic (and long-lasting) version of mRNA which is supposed to spark the creation of antibodies that attack spike proteins.

What happened next, according to public health officials and Pharma companies, is that the mRNA was extracted and purified, before being inserted into lipid nanoparticles (LNPs) which constitute the active part of the shots.

What researchers including Dr. Kevin McKernan discovered, however, is that while the mRNA was extracted in mostly pure form for Pfizer’s clinical study trials, once the shots were mass-manufactured, the filtration process often went awry, leaving contaminant plasmid DNA mingled with the mRNA and inserted together with it into the LNPs.

Zero possibility of harm? Based on zero evidence

Nobody knew for certain, a year ago, what this might mean for the people injected with these particles. The FDA and CDC (as well as regulatory and health agencies all around the world) insisted that the shots were still safe and that there was zero possibility of anything entering a person’s cell nucleus to alter DNA or do any other kind of damage.

Their claims rested largely on another claim — that the LNPs in the shots, which were injected into the shoulder muscle, stayed in the shoulder and didn’t migrate from the injection area. Since muscle cells don’t divide, this supposedly meant that the mRNA would do its job right there in the shoulder and then quietly die off before being flushed out of the body by the liver. 

It wasn’t long before this claim was debunked. In fact, it wasn’t difficult to debunk it, as Pfizer’s own study results showed that the LNPs were turning up all over the body, and not only that, were hanging around for weeks and months (and years?). But don’t worry, the authorities reiterated. They’re still safe and effective...

The gift that keeps on giving

Dr. McKernan wasn’t reassured by health officials and now, in an experiment conducted with Dr. Ulrike Kammerer, he has demonstrated how plasmid DNA contaminants from the shots (both Moderna and Pfizer) enter human cells and survive cell division, multiple times. Not only that, the contaminant itself replicates within the cells.

What we found is, [contaminant] DNA that is getting transfected into ovarian cancer cell lines is replicating in the cells…

If anything, this work has put to bed the question regarding if this contaminant DNA gets into the cell, and the chimeric human and contaminant spike DNA sequences imply it has entered the nucleus ... the sequencing data demonstrate the vaccine is getting into the cell and surviving cell passaging. It is likely bioactive and being partially replicated.

An infinity of unknowns

Dr. McKernan used ovarian cancer cell lines for his experiment, which means that the results may not be replicable when using non-cancerous cell lines. The experiment was also done in lab dishes rather than in humans. And it has yet to be discovered whether the integration into the cells is heritable or not.

Other unknowns are whether other components of the shots are integrated into cell nuclei as well. “The unknowns are just exponential,” says McKernan.

Worrying implications for cancer patients

Several scientists have suggested possible negative outcomes such as autoimmune disorders and even cancers. Dr. McKernan noted that his research indicated a likelihood that the cell integration could have a specifically bad impact on ovarian cancer patients in remission, especially as it is known that LNPs from the shots do reach the ovaries:

The study is performed in ovarian cancer cell lines ... this is a proxy for what might happen in an ovarian cancer patient who's in remission ... The risk for patients in this scenario is that integration events with contaminant DNA might cause aberrant cell growth, which poses a risk to immune suppression of new cancer cells.

Government officials now worried about taxpayer dollars?

The FDA, as noted above, denies that contaminant DNA can enter cell nuclei or pose any risk whatsoever to recipients of the shots. And the CDC continues to insist, without evidence, that “COVID-19 vaccines do not alter DNA.”

The genetic material delivered by mRNA vaccines never enters the nucleus of your cells, which is where your DNA is kept, so the vaccine does not alter your DNA.

Meanwhile, Dr. McKernan notes that avoiding this issue could have been relatively simple and even relatively inexpensive. There’s “no excuse” for regulators to not sequence every vaccine lot, he says. “DNA sequencing costs have dropped 100,000 fold in the last decade ... It likely only costs $1,000 in reagents for millions-to-billions of dollars worth of product.”