The devil hidden in the essential details: Analysis
by Arsenio Wall
Virologist and Pediatrician Dr. Paul Offit, involved with the FDA in the approval of mRNA-based vaccine platforms, in an interview with Gad Saad, made an important point regarding the difference in efficacy of vaccines against slow-incubating viruses such as measles and variola, which can be eradicated, and fast-incubating viruses such as influenza and coronavirus, which he said cannot be eradicated. This argument is orthogonal to the fact that eradication may be associated with the pathogen's ability to evade the conferred vaccine protection. Crucially, another aspect is the antibody-dependent enhancement (ADE) that led to the failure of the respiratory syncytial virus and rotavirus vaccine, in the development of which Offit himself was a part.
Surprisingly, Dr. Offit has not made a single mention of the fact that the mRNA vaccines for COVID-19 are based on the exposure to humans of a single toxic, hyperinflammatory protein (Spike) that is expressed in the human system longer than during a natural, acute infection. Very strange this omission! Here follows a list of other omissions, inconsistencies, and timely misunderstandings.
Another aspect that he does not point out is that natural cellular mRNA has a half-life of 9 to 10 hours and the vaccine synthetic mRNA used to express Spike may last for several days. Is it because it uses pseudouridine (Ψ) nucleotides? Pseudouridine occur naturally as 5% of the total ribonucleotide pool, but what would be the effect of substituting most uridines? Besides the protection of the vaccine mRNA provided by the delivery system consisting of lipid nanoparticle encapsulation, how would massive use of pseudouridines interfere in the cellular RNASES (RNA degrading enzymes) normal turnover of mRNA? Moreover, the vaccine mRNA has insertions of nucleotides other than adenine in the polyadenylated tail at the 3' position, which also could prevent 3'-5' exonucleases from degrading this chimeric molecule, apparently designed to be indestructible. In addition to changes in the 5’ domain of the vaccine mRNA that confer to it undue stability. In sum, this design generates synthetic mRNA molecules that express Spike for potentially an excessive long time, producing a neurotoxic, deleterious and mutagenic protein that causes serious multisystemic complications, in almost every tissue of the human body. Moreover, there is the possibility that the vaccine mRNA may integrate in human chromosomes assisted by reverse transcription activity provided possible by activated endogenous retroviruses, but this possibility was ignored in an educational video by Dr. Offit.
Moreover, it is surprising that he does not mention the polybasic site between the S1 and S2 domains of the vaccine Spike, enabling this Spike to be cleaved by the human Furin protease. This cleavage site, unique among betacoronaviruses, facilitates infection of human cells by SARS-CoV-2. Importantly, this attribute, possibly the result of gain-of-function experiments, would have been patented years before the 2019 outbreak in Wuhan.
Researcher Alba Grifoni from La Jolla showed that there are 25 proteins expressed by SAR-CoV-2 that induce immune response in humans. Today we know that Spike is not even the main protein to generate prolonged immunity and with cross-reactivity between divergent viral strains, as is the case with nucleoprotein (N), so it would be expected that Spike-based vaccines would be universally understood by now as the fruit of a dangerously misguided and outdated concept. Dr. Offit was also mistaken in saying that betacoronaviruses do not have an oral-fecal component in their replication cycle. This is widely known about bat betacoronaviruses (associated to the SAR-CoV-1 and 2) and has been demonstrated for SARS-CoV-1 in Asia and demonstrated for SARS-CoV-2 in Singapore in 2020 and appears to be well established. It is very hard not to see this omission as a convenience for those who are in favor of lockdowns, given that this aspect of the biology of betacoronaviruses would facilitate viral spread indoors via the oral-fecal cycle.
Furthermore, despite the knownantiviral activity of Hydroxychloroquine for a long time, Dr. Offit’s assertion that hydroxychloroquine is ineffective and causes cardiac problems in the context of early COVID-19 therapy is contradicted by 380 studies of 8,151 scientists, involving 497,516 patients in 55 countries. He certainly dismissed the study on Hydroxychloroquine conducted at the Henry Ford Health System Hospital in Ohio in 2020, showing significant mortality risk reduction and a letter from Dr. Sidney Goldstein, Wayne State University School of Medicine, the Chairman of the Data Safety Monitoring Board (See figure), stating a lack of cardiac problems reported by the mainstream media? Unfortunately, despite the important results of the trial it was shut down by heavyweights such the notorious Dr. Fauci and the media. All of this was necessary for the issuing of emergency used authorization (EUA) for the COVID vaccines hurriedly produced at “the speed of Science”.
Dr. Offit, during the entire interview, obviously dismisses or downplays all the known and blossoming evidence on COVID-19 vaccine adverse effects that unfortunately are touted as “antivaxxer activism” despite evidence otherwise, especially on the mounting evidence on recent increase in excess mortality. The devil is in the details.
